Description

(S)-1,4-Dichloro-2-Butanol is a chiral chlorinated alcohol of significant interest in advanced organic synthesis. This compound matters as a versatile and valuable chiral building block for the production of pharmaceuticals and fine chemicals, enabling the construction of complex molecules with high stereochemical fidelity. Industries that require enantiomerically pure intermediates, such as pharmaceutical R&D, agrochemical manufacturing, and specialty chemical synthesis, are the primary users of this material.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system and cardiovascular diseases.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides and pesticides, where the specific stereochemistry can be critical for biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Building Block: Employed in the multistep synthesis of complex natural products, flavors, and fragrances requiring defined stereocenters.
• Material Science Research: Investigated as a monomer or modifying agent for creating chiral polymers with specialized optical or mechanical properties.

Basic Information

Product Name	(S)-1,4-Dichloro-2-Butanol
CAS No.	847375-52-4
Molecular Formula	C4H8Cl2O
Molecular Weight	143.01 g/mol
Synonyms	(S)-1,4-Dichlorobutan-2-ol; (2S)-1,4-Dichloro-2-butanol; (S)-1,4-Dichloro-2-hydroxybutane; (S)-2-Butanol, 1,4-dichloro-; (S)-1,4-Dichlorobutan-2-ol; (S)-1,4-Dichloro-2-butanol; (S)-1,4-Dichloro-butane-2-ol; (S)-1,4-Dichloro-2-butanol (enantiomer)
EINECS	Contact for details

Quality Control

Our (S)-1,4-Dichloro-2-Butanol is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, identity confirmation by IR and NMR, and impurity profiling. A detailed Certificate of Analysis (COA) documenting purity, assay, and specific rotation is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.