Description

(R)-tert-Butyl (1-(1H-Indol-3-Yl)Propan-2-Yl)Carbamate is a chiral, non-natural amino acid derivative featuring an indole moiety, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the stereoselective construction of complex molecules, particularly in pharmaceutical research and development. This high-purity intermediate is essential for medicinal chemists and process development scientists working on novel therapeutics, including peptide mimetics and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery.
• Peptidomimetics: Used to incorporate unnatural, sterically hindered amino acid units into peptide chains to enhance metabolic stability, bioavailability, and receptor selectivity.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric transformations to create enantiomerically pure compounds.
• Protease Inhibitor Development: The indole and carbamate functional groups make it a valuable scaffold for designing inhibitors of specific proteases and other enzymes.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds or molecular probes for studying biological pathways and target engagement.
• Process Chemistry: Serves as a validated intermediate in the scale-up and optimization of synthetic routes for candidate drugs under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	(R)-tert-Butyl (1-(1H-Indol-3-Yl)Propan-2-Yl)Carbamate
CAS No.	847199-90-0
Molecular Formula	C₁₆H₂₂N₂O₂
Molecular Weight	274.36 g/mol
Synonyms	(R)-1-(1H-Indol-3-yl)-2-((tert-butoxycarbonyl)amino)propane; (R)-N-Boc-1-(1H-indol-3-yl)-2-aminopropane; (R)-tert-Butyl 1-(1H-indol-3-yl)propan-2-ylcarbamate; (R)-Boc-Trp(Me)-OH (analog); (R)-2-((tert-Butoxycarbonyl)amino)-1-(1H-indol-3-yl)propane; (R)-N-(tert-Butoxycarbonyl)-1-(1H-indol-3-yl)-2-aminopropane; (R)-1-(1H-Indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propane
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl (1-(1H-Indol-3-Yl)Propan-2-Yl)Carbamate is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), chiral purity (≥99% ee), and impurity profiles. We adhere to ICH Q7 guidelines for active pharmaceutical ingredients (APIs) and can provide material suitable for research and development under non-GMP or GMP conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.