Description

3-(1,2,3,4-Tetrahydroisoquinoline-2-Yl)-Propionic Acid Hydrochloride is a high-purity organic salt compound, serving as a critical building block in advanced pharmaceutical synthesis. Its value lies in its role as a versatile intermediate for constructing complex nitrogen-containing heterocycles, which are core structures in many active pharmaceutical ingredients. This product is essential for research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for API development.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of central nervous system (CNS) active compounds and other therapeutic agents featuring the tetrahydroisoquinoline scaffold.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides that utilize nitrogen heterocycles for bioactivity.
• Fine Chemical Building Block: Employed in custom synthesis and contract manufacturing for producing specialty chemicals and complex organic molecules.
• Academic & Industrial Research: Serves as a standard or starting material in medicinal chemistry programs for drug discovery and lead optimization.
• Process Chemistry Development: Utilized in route scouting and optimization for the scalable production of target molecules in kilo lab and pilot plant settings.

Basic Information

Product Name	3-(1,2,3,4-Tetrahydroisoquinoline-2-Yl)-Propionic Acid Hydrochloride
CAS No.	846576-15-6
Molecular Formula	C₁₂H₁₆ClNO₂
Molecular Weight	241.71 g/mol
Synonyms	2-(3-Carboxypropyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; 3-(1,2,3,4-Tetrahydro-2-isoquinolinyl)propanoic acid hydrochloride; 3-(3,4-Dihydro-1H-isoquinolin-2-yl)propionic acid HCl; THIQ-Propionic Acid HCl; 1,2,3,4-Tetrahydroisoquinoline-2-propionic acid hydrochloride; 2-(3-Carboxypropyl)-3,4-dihydro-1H-isoquinoline hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(1,2,3,4-Tetrahydroisoquinoline-2-Yl)-Propionic Acid Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request. We support development with custom purity grades and specifications tailored to your process needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.