Description

(1S,4S)-(+)-2-(4-Trifluoromethyl-Benzyl)-2,5-Diaza-Bicyclo[2.2.1]Heptane 2Cf3Cooh is a high-purity, chiral bicyclic diamine derivative, distinguished by its trifluoromethyl benzyl substituent. This compound is a critical advanced pharmaceutical intermediate (API intermediate) and a versatile chiral building block for asymmetric synthesis. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active compounds, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral scaffold in the synthesis of novel drug candidates, especially for neurological and psychiatric applications.
• Ligand for Asymmetric Catalysis: Serves as a precursor for chiral ligands used in metal-catalyzed asymmetric reactions to create enantiomerically pure compounds.
• Agrochemical Research: Used in the development of new, more effective pesticides and herbicides with chiral centers.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead molecules.
• Process Chemistry Development: Used in scaling up synthetic routes for active pharmaceutical ingredients (APIs) requiring this specific chiral diamine framework.
• Academic & Industrial R&D: A valuable tool for chemists in universities and corporate labs exploring new synthetic methodologies and bioactive molecules.

Basic Information

Product Name	(1S,4S)-(+)-2-(4-Trifluoromethyl-Benzyl)-2,5-Diaza-Bicyclo[2.2.1]Heptane 2Cf3Cooh
CAS No.	845866-70-8
Molecular Formula	C15H16F3N2O2
Molecular Weight	313.30 g/mol
Synonyms	(1S,4S)-2-[(4-Trifluoromethyl)benzyl]-2,5-diazabicyclo[2.2.1]heptane; (1S,4S)-(+)-2-(4-Trifluoromethylbenzyl)-2,5-diazabicyclo[2.2.1]heptane; 2,5-Diaza-bicyclo[2.2.1]heptane, 2-[(4-(trifluoromethyl)phenyl)methyl]-, (1S,4S)-; (1S,4S)-2-(4-(Trifluoromethyl)benzyl)-2,5-diazabicyclo[2.2.1]heptane; Bicyclic Diamine CF3 Derivative; Chiral Trifluoromethyl Diazabicycloheptane
EINECS	Contact for details

Quality Control

Our production of (1S,4S)-(+)-2-(4-Trifluoromethyl-Benzyl)-2,5-Diaza-Bicyclo[2.2.1]Heptane 2Cf3Cooh adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized and tested against rigorous in-house specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC/Chiral HPLC), and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.