Description

3-Chloro-5-Fluorothiophenol is a versatile and high-value organosulfur building block characterized by its unique halogenated thiophenol structure. This compound is essential for the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research where the introduction of sulfur and halogen functionalities is critical. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing benzothiophene or diaryl sulfide scaffolds.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogen and sulfur groups for bioactivity.
• Ligand and Catalyst Preparation: Serves as a building block for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and organic electronic materials due to its aromatic and thiol functionality.
• Chemical Biology Probes: Useful for synthesizing probes and linkers in bioconjugation and protein labeling studies.
• Custom Synthesis and Contract Manufacturing: A critical raw material for fine chemical manufacturers offering bespoke synthesis services.

Basic Information

Product Name	3-Chloro-5-Fluorothiophenol
CAS No.	845823-02-1
Molecular Formula	C6H4ClFS
Molecular Weight	162.61 g/mol
Synonyms	3-Chloro-5-fluorobenzenethiol; 3-Chloro-5-fluorothiophenol; 3-Chloro-5-fluorophenyl mercaptan; 1-Chloro-3-fluoro-5-mercaptobenzene; Benzenethiol, 3-chloro-5-fluoro-; 3-Fluoro-5-chlorothiophenol; (3-Chloro-5-fluorophenyl)thiol
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Fluorothiophenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its sensitivity to oxidation and light, prolonged exposure to air or light should be avoided. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.