Description

4-(3-Fluorophenyl)Thiophenol is a specialized aromatic thiol compound featuring a fluorinated phenyl ring, making it a valuable building block in advanced organic synthesis. Its unique structure provides a reactive thiol group and a fluorine substituent, enabling precise modifications to enhance the properties of target molecules. This intermediate is primarily sought by researchers and manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom can improve biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands in transition metal catalysis and asymmetric synthesis.
• Polymer Modification: Employed to introduce thiol and fluorinated aromatic functionalities into polymer backbones, altering material properties like adhesion and chemical resistance.
• Material Science Research: Used in the synthesis of organic electronic materials, such as charge-transport layers or sensitizers, due to its electron-rich thiophenol moiety.
• Chemical Biology Probes: Acts as a building block for creating probes and linkers in bioconjugation and protein engineering studies.

Basic Information

Product Name	4-(3-Fluorophenyl)Thiophenol
CAS No.	845822-98-2
Molecular Formula	C12H9FS
Molecular Weight	204.26 g/mol
Synonyms	3-Fluoro-4-mercaptobiphenyl; 4-(3-Fluorophenyl)benzenethiol; 3-Fluorophenyl-4-thiophenol; (3-Fluorophenyl)-4-thiophenol; 1-Fluoro-3-(4-mercaptophenyl)benzene; 4-Mercapto-3'-fluorobiphenyl; 3'-Fluoro[1,1'-biphenyl]-4-thiol
EINECS	Contact for details

Quality Control

Our production of 4-(3-Fluorophenyl)Thiophenol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR) to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. Due to the thiol functionality, it is recommended to store under an inert atmosphere (e.g., nitrogen) for long-term stability to prevent oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.