Description

3-Bromo-3',3''-Dichlorotrityl Alcohol is a specialized trityl-protecting group reagent, a key intermediate in modern organic synthesis. Its value lies in its unique halogenated structure, which offers enhanced stability and orthogonal deprotection capabilities compared to standard trityl groups. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the solid-phase synthesis of oligonucleotides, peptides, and complex natural products where precise and selective protection of hydroxyl groups is required.

Application

• Oligonucleotide Synthesis: As a protecting group for the 5'-hydroxyl function of nucleosides in solid-phase phosphoramidite chemistry.
• Peptide Synthesis: For the selective protection of serine, threonine, or tyrosine side-chain hydroxyl groups during fragment condensation strategies.
• Carbohydrate Chemistry: Employed in the synthesis of complex glycans and glycosides to protect specific hydroxyl positions.
• Natural Product Synthesis: A critical reagent for constructing polyhydroxylated segments of macrolides, polyethers, and other bioactive molecules.
• Intermediate for Functionalized Resins: Used to prepare specialized solid supports for combinatorial chemistry and library synthesis.
• Material Science Research: As a building block for creating novel dendritic polymers and functional organic materials.

Basic Information

Item	Details
Product Name	3-Bromo-3',3''-Dichlorotrityl Alcohol
CAS No.	845790-86-5
Molecular Formula	C20H13BrCl2O
Molecular Weight	420.53 g/mol
Synonyms	3-Bromo-3',3''-Dichlorotrityl Alcohol; BDTr-OH; 3-Bromo-3',5''-Dichlorotrityl Alcohol; (3-Bromophenyl)bis(3-chlorophenyl)methanol; α-(3-Bromophenyl)-α,α-bis(3-chlorophenyl)methanol; Bromo-Dichloro-Trityl Alcohol; BDTr Alcohol; 3-Br-3',3''-Cl2-Tr-OH
EINECS	Contact for details

Quality Control

Our 3-Bromo-3',3''-Dichlorotrityl Alcohol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere to prevent moisture absorption and oxidation. Handle and store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.