Description

4-Bromo-4',4''-Dichlorotrityl Alcohol is a specialized trityl-protecting group reagent used in synthetic organic chemistry, particularly in oligonucleotide and peptide synthesis. Its value lies in its selective reactivity, which allows for the protection of specific functional groups during complex multi-step syntheses. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for their synthetic workflows.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Used as a key protecting group reagent for the 5'-hydroxyl function of nucleosides, enabling the controlled assembly of DNA and RNA strands.
• Peptide Synthesis: Employed for the temporary protection of hydroxyl groups on serine, threonine, or tyrosine residues during fragment condensation or solid-phase peptide synthesis.
• Intermediate in Fine Chemical Production: Serves as a crucial synthetic intermediate in the manufacture of more complex, high-value specialty chemicals and active pharmaceutical ingredients (APIs).
• Academic and Industrial R&D: A vital tool in research laboratories for developing new synthetic methodologies and constructing novel molecular architectures.
• Protecting Group Chemistry: Provides a robust, acid-labile protecting group that can be selectively removed under mild conditions without affecting other sensitive functionalities.

Basic Information

Product Name	4-Bromo-4',4''-Dichlorotrityl Alcohol
CAS No.	845790-83-2
Molecular Formula	C20H13BrCl2O
Molecular Weight	420.13 g/mol
Synonyms	4-Bromo-4',4''-dichlorotrityl alcohol; 4-Bromo-α,α-bis(4-chlorophenyl)benzenemethanol; BDCT-OH; (4-Bromophenyl)bis(4-chlorophenyl)methanol; 4-Bromo-4',4''-dichlorotriphenylmethanol; 4-Bromo-4',4''-dichlorotrityl alcohol (BDCT-OH); 4-Bromo-α,α-bis(p-chlorophenyl)benzenemethanol
EINECS	Contact for details

Quality Control

Our 4-Bromo-4',4''-Dichlorotrityl Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider sealing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.