Description

4-Bromo-3',3''-Difluorotrityl Alcohol is a specialized trityl-protecting group reagent used in synthetic organic chemistry. This compound is valued for its role in the selective protection of hydroxyl groups, particularly in the synthesis of complex molecules like oligonucleotides and pharmaceuticals. It is a critical intermediate for researchers and manufacturers in the fields of nucleoside chemistry, peptide synthesis, and fine chemical production, where high-purity building blocks are essential.

Application

• Oligonucleotide Synthesis: As a key protecting group reagent for the 5'-hydroxyl function in phosphoramidite-based solid-phase synthesis.
• Pharmaceutical Intermediates: Used in the multi-step synthesis of active pharmaceutical ingredients (APIs) and drug candidates requiring selective protection strategies.
• Peptide Chemistry: Employed for the temporary protection of serine, threonine, or tyrosine side chains during peptide assembly.
• Glycosylation Reactions: Serves as a protecting group in the synthesis of complex carbohydrates and glycoconjugates.
• Material Science Research: Utilized in the development of novel polymers and dendrimers where controlled functionalization is needed.
• Chemical Biology Probes: Acts as a precursor for labeling reagents and molecular probes used in biochemical assays.

Basic Information

Product Name	4-Bromo-3',3''-Difluorotrityl Alcohol
CAS No.	845790-81-0
Molecular Formula	C20H14BrF2O
Molecular Weight	397.23 g/mol
Synonyms	4-Bromo-3',3''-difluorotrityl alcohol; 4-Bromo-α,α-bis(3-fluorophenyl)benzenemethanol; 4-Bromo-α,α-bis(3-fluorophenyl)benzyl alcohol; 4-Bromo-DFTr-OH; 4-Bromo-DFTr alcohol; (4-Bromophenyl)bis(3-fluorophenyl)methanol; 4-Bromo-α,α-di(3-fluorophenyl)benzyl alcohol
EINECS	Contact for details

Quality Control

Our production of 4-Bromo-3',3''-Difluorotrityl Alcohol adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.