Description

3-Bromo-3',3''-Dimethoxytrityl Alcohol is a specialized trityl-protecting group reagent used in synthetic organic chemistry, particularly in oligonucleotide and peptide synthesis. Its core value lies in its selective reactivity, which allows for the efficient protection of hydroxyl groups during complex multi-step syntheses. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries who require high-purity intermediates for the development of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Oligonucleotide Synthesis: As a key protecting group reagent for the 5'-hydroxyl function in phosphoramidite-based solid-phase DNA/RNA synthesis.
• Peptide Synthesis: For the selective protection of serine, threonine, or tyrosine side chains during solution or solid-phase peptide synthesis (SPPS).
• Intermediate for API Production: Serves as a critical building block in the multi-step synthesis of complex drug molecules and other biologically active compounds.
• Carbohydrate Chemistry: Used in the protection of hydroxyl groups during the synthesis of complex sugars and glycoconjugates.
• Material Science Research: Employed in the development of novel polymers and dendrimers where controlled functionalization is required.
• Process Development & Scale-up: Supplied in bulk quantities for process research and development (PR&D) and commercial-scale manufacturing campaigns.

Basic Information

Product Name	3-Bromo-3',3''-Dimethoxytrityl Alcohol
CAS No.	845790-80-9
Molecular Formula	C23H21BrO4
Molecular Weight	465.32 g/mol
Synonyms	3-Bromo-3',3''-dimethoxytrityl alcohol; 3-Bromo-DMT-OH; 3-Br-DMT-OH; 3-Bromo-4,4'-dimethoxytrityl alcohol; (3-Bromophenyl)bis(4-methoxyphenyl)methanol; 3-Bromo-α,α-bis(4-methoxyphenyl)benzenemethanol
EINECS	Contact for details

Quality Control

Our 3-Bromo-3',3''-Dimethoxytrityl Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions (e.g., nitrogen or argon atmosphere) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.