Description

4-Bromo-3',3''-Dimethoxytrityl Alcohol is a specialized trityl-protecting group reagent, a key intermediate in the synthesis of oligonucleotides and other sensitive biomolecules. Its value lies in providing a robust, selectively removable protecting group for primary alcohols, particularly in automated solid-phase synthesis where high coupling efficiency and stability are critical. This compound is essential for research and production facilities in the pharmaceutical, biotechnology, and diagnostic sectors developing nucleic acid-based therapeutics, probes, and primers.

Application

• Oligonucleotide Synthesis: As a key protecting group reagent for the 5'-hydroxyl group of nucleosides in phosphoramidite-based solid-phase synthesis.
• Pharmaceutical Intermediates: Serving as a critical building block in the production of active pharmaceutical ingredients (APIs) for antisense oligonucleotides and siRNA therapeutics.
• Research & Development: Used in academic and industrial R&D labs for the study and development of novel nucleic acid analogs and modified oligonucleotides.
• Diagnostic Probe Manufacturing: Employed in the synthesis of labeled probes for genetic testing, fluorescence in situ hybridization (FISH), and other molecular diagnostic applications.
• Scale-Up cGMP Production: Suitable for use in current Good Manufacturing Practice (cGMP) environments for the commercial-scale manufacturing of therapeutic oligonucleotides.

Basic Information

Item	Detail
Product Name	4-Bromo-3',3''-Dimethoxytrityl Alcohol
CAS No.	845790-79-6
Molecular Formula	C23H21BrO3
Molecular Weight	425.32 g/mol
Synonyms	4-Bromo-DMT-OH; 4-Bromo-3',3''-Dimethoxytrityl Alcohol; 4-Bromo-DMTr Alcohol; 4-Bromo-3',3''-Dimethoxytrityl Hydroxide; [(4-Bromophenyl)bis(3-methoxyphenyl)methyl]methanol; 4-Bromo-DMTr; Br-DMT Alcohol; 4-Bromo-3',3''-Dimethoxytriphenylmethanol
EINECS	Contact for details

Quality Control

Our 4-Bromo-3',3''-Dimethoxytrityl Alcohol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive oligonucleotide synthesis. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with the standards required for pharmaceutical intermediates and advanced research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.