Description

3-Bromo-4',4''-Difluorotrityl Alcohol is a specialized trityl-protecting group reagent with a bromine substituent and fluorine atoms on the aromatic rings. This compound is critical for the controlled synthesis of complex molecules, particularly in oligonucleotide and peptide chemistry, where it offers enhanced stability and selective deprotection profiles. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of advanced therapeutics, diagnostics, and high-value fine chemicals.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Serves as a key protecting group for the 5'-hydroxyl function of nucleosides, enabling the sequential assembly of DNA/RNA strands.
• Peptide Synthesis: Used for the protection of sensitive functional groups during the synthesis of complex peptides and peptide conjugates.
• Pharmaceutical Intermediate: Acts as a crucial building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) and prodrugs.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating novel molecular architectures.
• Diagnostic Reagent Manufacturing: Utilized in the production of labeled probes and other diagnostic components requiring high-purity intermediates.
• Material Science: Investigated for the synthesis of specialized polymers and advanced organic materials with tailored properties.

Basic Information

Product Name	3-Bromo-4',4''-Difluorotrityl Alcohol
CAS No.	845790-78-5
Molecular Formula	C20H13BrF2O
Molecular Weight	387.22 g/mol
Synonyms	3-Bromo-4',4''-Difluoro Trityl Alcohol; 3-Bromo-4',4''-Difluoro Triphenylmethyl Alcohol; 3-Bromo-4',4''-Difluoro Tritylol; 3-Bromo-4',4''-Difluoro Triphenylmethanol; 3-Bromo-4',4''-Difluoro Trityl-OH; 3-Bromo-4',4''-Difluoro DMT-OH; 3-Br-4',4''-F2Tr-OH; (3-Bromophenyl)bis(4-fluorophenyl)methanol
EINECS	Contact for details

Quality Control

Our 3-Bromo-4',4''-Difluorotrityl Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.