Description

3-Bromo-4',4''-Dimethoxytrityl Alcohol is a specialized trityl-protected alcohol derivative, a key intermediate in synthetic organic chemistry. Its primary value lies in its role as a versatile protecting group reagent, particularly for the selective protection of hydroxyl groups during complex multi-step syntheses. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, especially those developing nucleoside analogs, oligonucleotides, and other fine chemicals where precise molecular assembly is critical.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer nucleoside drugs.
• Oligonucleotide Synthesis: Used as a protecting group reagent for the 5'-hydroxyl function in solid-phase phosphoramidite chemistry during DNA/RNA oligonucleotide manufacturing.
• Protecting Group Chemistry: Serves as a robust and selectively removable protecting agent for primary and secondary alcohols in complex multi-step organic syntheses.
• Bioconjugation & Labeling: Acts as a precursor for developing specialized linkers and tags used in bioconjugation strategies for diagnostics and targeted therapies.
• Academic & Industrial R&D: Employed in research laboratories for method development and the synthesis of novel chemical entities for screening and evaluation.
• Fine Chemical Production: Integral to the custom synthesis of high-value, low-volume specialty chemicals for advanced material science and agrochemical applications.

Basic Information

Product Name	3-Bromo-4',4''-Dimethoxytrityl Alcohol
CAS No.	845790-76-3
Molecular Formula	C23H21BrO3
Molecular Weight	425.32 g/mol
Synonyms	3-Bromo-DMT-OH; 3-Bromo-4',4''-Dimethoxytritylol; 3-Br-DMT Alcohol; (3-Bromophenyl)bis(4-methoxyphenyl)methanol; 3-Bromo-α,α-bis(4-methoxyphenyl)benzenemethanol; 3-Bromo-4',4''-dimethoxytrityl alcohol; 3-Bromo-DMTr-OH
EINECS	Contact for details

Quality Control

Our 3-Bromo-4',4''-Dimethoxytrityl Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for pharmaceutical and biotech applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.