Description

(R)-α-Amino-2,3-Dihydro-4-Methoxy-7-Nitro-γ-Oxo-1H-Indole-1-Butanoicacid CAS NO 845555-94-4 is a high-purity, non-natural amino acid derivative featuring a complex indole-based structure. This compound is a critical chiral building block for the synthesis of advanced pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and process development. The specific stereochemistry and functional groups make it valuable for creating molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and oncology research.
• Peptidomimetic & Drug Discovery: Serves as a constrained, non-proteinogenic amino acid analog for designing peptide-based drugs and peptidomimetics with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Used as a starting material or reagent in asymmetric catalytic reactions to introduce chirality into complex molecular frameworks.
• Biochemical Research: Employed in academic and industrial R&D for studying enzyme-substrate interactions, receptor binding, and structure-activity relationships (SAR).
• API Process Development: Integral to the development and scale-up of synthetic routes for candidate drugs during preclinical and clinical stages.
• Reference Standard: Can be supplied as a high-purity certified reference material (CRM) for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	(R)-α-Amino-2,3-Dihydro-4-Methoxy-7-Nitro-γ-Oxo-1H-Indole-1-Butanoicacid
CAS No.	845555-94-4
Molecular Formula	C₁₃H₁₅N₃O₆
Molecular Weight	309.28 g/mol
Synonyms	(R)-2-Amino-3-(4-methoxy-7-nitro-2,3-dihydro-1-oxo-1H-indol-1-yl)butanoic acid; (R)-α-Amino-4-methoxy-7-nitroindoline-1-butyric acid; (R)-Amino Dihydro Methoxy Nitro Oxo Indole Butanoic Acid; (R)-ADMNOIB; (R)-Indoline-1-butyric acid derivative; (1R)-1-(1-Amino-3-carboxypropyl)-4-methoxy-7-nitroindolin-2-one
EINECS	Contact for details

Quality Control

Our (R)-α-Amino-2,3-Dihydro-4-Methoxy-7-Nitro-γ-Oxo-1H-Indole-1-Butanoicacid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We can support development with custom purity grades and specifications aligned with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.