Description

4-Nitro-5-Piperazinothiophene-2-Sulfonamide is a specialized heterocyclic sulfonamide derivative of significant interest in advanced organic synthesis. This compound serves as a critical synthetic intermediate and building block for the development of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the discovery and optimization of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting enzymes where the sulfonamide and nitro-thiophene pharmacophores are relevant.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and combinatorial chemistry libraries to explore new chemical entities for various therapeutic areas.
• Chemical Biology Probes: Serves as a precursor for developing molecular probes to study biological pathways and protein functions.
• Agrochemical Research: Potential intermediate in the research and development of new active ingredients for crop protection products.
• Material Science: Can be investigated as a monomer or precursor for specialty polymers and advanced organic materials with specific electronic properties.

Basic Information

Product Name	4-Nitro-5-Piperazinothiophene-2-Sulfonamide
CAS No.	845266-27-5
Molecular Formula	C8H11N5O4S2
Molecular Weight	305.33 g/mol
Synonyms	4-Nitro-5-(piperazin-1-yl)thiophene-2-sulfonamide; 5-Piperazinyl-4-nitro-2-thiophenesulfonamide; Thiophene-2-sulfonamide, 4-nitro-5-(1-piperazinyl)-; 845266-27-5; 4-Nitro-5-piperazin-1-ylthiophene-2-sulfonamide
EINECS	Contact for details

Quality Control

Our 4-Nitro-5-Piperazinothiophene-2-Sulfonamide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing all specifications is available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	Yellow to brown powder or crystalline solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.