Description

3-(4-Bromophenyl)-4-Hydroxy-6-Oxo-6,7-Dihydrothieno[2,3-B]Pyridine-5-Carbonitrile is a high-purity, advanced pharmaceutical intermediate with a complex fused-ring heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, especially within oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Oncology Drug Development: Used in the research and synthesis of potential kinase inhibitors and other targeted cancer therapies.
• CNS-Active Compound Synthesis: Employed in the development of new chemical entities for neurological and psychiatric disorders.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for pharmaceutical clients.
• Academic Research: Utilized in university and institutional labs for heterocyclic chemistry studies and the exploration of new synthetic methodologies.

Basic Information

Product Name	3-(4-Bromophenyl)-4-Hydroxy-6-Oxo-6,7-Dihydrothieno[2,3-B]Pyridine-5-Carbonitrile
CAS No.	844499-56-5
Molecular Formula	C14H7BrN2O2S
Molecular Weight	347.19 g/mol
Synonyms	4-Hydroxy-3-(4-bromophenyl)-6-oxo-6,7-dihydro-5H-thieno[2,3-b]pyridine-5-carbonitrile; 3-(4-Bromophenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile; Thieno[2,3-b]pyridine-5-carbonitrile, 6,7-dihydro-3-(4-bromophenyl)-4-hydroxy-6-oxo-; 844499-56-5; 5-Cyano-3-(4-bromophenyl)-4-hydroxy-6,7-dihydrothieno[2,3-b]pyridin-6-one
EINECS	Contact for details

Quality Control

Our production of 3-(4-Bromophenyl)-4-Hydroxy-6-Oxo-6,7-Dihydrothieno[2,3-B]Pyridine-5-Carbonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. All materials undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and analytical results is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.