Description

Hexadecanedioic Acid tert-Butyl Ester n-Hydroxysuccinimide Ester is a high-purity, bifunctional chemical intermediate designed for advanced synthesis. This compound is critical for researchers and manufacturers requiring precise, stable conjugation and cross-linking in complex molecular architectures. It is primarily utilized in the development of pharmaceuticals, advanced materials, and specialty polymers where controlled functionalization is paramount.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, particularly in linker chemistry for antibody-drug conjugates (ADCs).
• Bioconjugation Reagent: Used to covalently attach molecules (e.g., drugs, dyes, peptides) to proteins, antibodies, or other biomolecules under mild conditions.
• Polymer Chemistry: Serves as a monomer or cross-linking agent in the production of specialty polyesters, polyamides, and biodegradable polymers with tailored properties.
• Material Science: Employed in surface modification and the creation of functionalized coatings, hydrogels, and nanomaterials.
• Peptide Synthesis: Acts as an activating ester for the efficient coupling of long-chain dicarboxylic acid derivatives in solid-phase peptide synthesis (SPPS).
• Research & Development: Essential tool compound in chemical biology and medicinal chemistry for probe and sensor development.

Basic Information

Product Name	Hexadecanedioic Acid tert-Butyl Ester n-Hydroxysuccinimide Ester
CAS No.	843666-28-4
Molecular Formula	C24H41NO6
Molecular Weight	439.59 g/mol
Synonyms	1,16-Hexadecanedioic Acid 1-tert-Butyl Ester 16-(2,5-Dioxo-1-pyrrolidinyl) Ester; Thapsic Acid tert-Butyl Ester NHS Ester; NHS Ester of tert-Butyl Thapsate; 16-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-16-oxohexadecanoic Acid 1,1-Dimethylethyl Ester; tert-Butyl 16-((2,5-dioxopyrrolidin-1-yl)oxy)-16-oxohexadecanoate; Bifunctional C16 NHS Ester; Thapsic Acid tert-Butyl Ester N-Hydroxysuccinimide Ester
EINECS	Contact for details

Quality Control

Our Hexadecanedioic Acid tert-Butyl Ester n-Hydroxysuccinimide Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.