Description

1-(tert-Butyl) 5-(2,5-Dioxopyrrolidin-1-Yl) (16-(tert-Butoxy)-16-Oxohexadecanoyl)-L-Glutamate is a sophisticated, multi-functional chemical building block designed for advanced synthesis. This compound is critical for researchers and manufacturers requiring high-purity, reactive intermediates for constructing complex molecular architectures. It is primarily utilized in the development of novel pharmaceuticals, peptide-based therapeutics, and specialized materials where precise chemical linkage is paramount.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptide-derived drugs and targeted therapies.
• Bioconjugation Reagent: Used for coupling biomolecules (e.g., peptides, proteins, antibodies) to other entities like drug payloads, polymers, or fluorescent tags via its reactive ester group.
• Prodrug Synthesis: Enables the creation of prodrugs by attaching promoieties (like the tert-butyl groups) to active compounds to improve solubility, stability, or bioavailability.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating functionalized polymers with specific biological or chemical properties.
• Chemical Biology Research: A valuable tool for probing biological systems, labeling biomolecules, and developing new diagnostic assays.
• Linker Chemistry: The structure acts as a cleavable or stable linker in drug delivery systems, such as antibody-drug conjugates (ADCs).

Basic Information

Item	Details
Product Name	1-(tert-Butyl) 5-(2,5-Dioxopyrrolidin-1-Yl) (16-(tert-Butoxy)-16-Oxohexadecanoyl)-L-Glutamate
CAS No.	843666-26-2
Molecular Formula	C34H58N2O9
Molecular Weight	638.84 g/mol
Synonyms	Nα-(tert-Butoxycarbonyl)-Nε-(16-tert-butoxy-16-oxohexadecanoyl)-L-lysine N-hydroxysuccinimide ester; Boc-Lys(Hexadecanoyl(t-Bu ester))-OSu; Nα-Boc-Nε-(16-tert-butoxy-16-oxohexadecanoyl)-L-lysine N-succinimidyl ester; (16-(tert-Butoxy)-16-oxohexadecanoyl)-L-glutamic acid 1-tert-butyl 5-(2,5-dioxo-1-pyrrolidinyl) ester; Glutamic acid derivative CAS 843666-26-2; Boc-Lys(C16(t-Bu ester))-OSu; Long-chain fatty acid glutamate ester
EINECS	Contact for details

Quality Control

Our 1-(tert-Butyl) 5-(2,5-Dioxopyrrolidin-1-Yl) (16-(tert-Butoxy)-16-Oxohexadecanoyl)-L-Glutamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 99.0% L-isomer
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.