Description

1-(4-Bromobutyl)-5-Fluoro-1H-Indole is a high-purity, advanced pharmaceutical intermediate characterized by its bromobutyl and fluoroindole functional groups. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel bioactive molecules. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in oncology and CNS drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fluorinated Compound Synthesis: The 5-fluoroindole moiety makes it valuable for introducing fluorine atoms into target molecules to enhance metabolic stability and bioavailability.
• Alkylation Reagent: The reactive 4-bromobutyl side chain enables its use as an alkylating agent in organic synthesis to construct more complex molecular architectures.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for investigating new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	1-(4-Bromobutyl)-5-Fluoro-1H-Indole
CAS No.	843653-06-5
Molecular Formula	C₁₂H₁₃BrFN
Molecular Weight	270.14 g/mol
Synonyms	5-Fluoro-1-(4-bromobutyl)-1H-indole; 1H-Indole, 1-(4-bromobutyl)-5-fluoro-; 5-Fluoro-1-(4-bromobutyl)indole; 1-(4-Bromobutyl)-5-fluoroindole; 843653-06-5; 5-Fluoro-1-(4-bromobutyl)indole; 1-(4-Bromobutyl)-5-fluoro-1H-indole
EINECS	Contact for details

Quality Control

Our 1-(4-Bromobutyl)-5-Fluoro-1H-Indole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.