Description

5-Fluoro-3-Formyl-1H-Indole-2-Carboxylic Acid Methyl Ester is a high-value, multi-functional indole derivative serving as a critical synthetic building block in advanced organic chemistry. Its molecular architecture, featuring both a formyl and an ester group on the indole core, makes it an indispensable precursor for constructing complex heterocyclic systems and active pharmaceutical ingredients (APIs). This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key starting material for the synthesis of potent drug candidates, particularly in oncology and central nervous system (CNS) research.
• Agrochemical Development: Used in creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Organic Synthesis Building Block: The reactive aldehyde and ester groups facilitate further functionalization, enabling the construction of complex indole-based libraries for high-throughput screening.
• Material Science Research: Employed in the development of organic semiconductors, fluorescent dyes, and other advanced functional materials.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis projects and scale-up processes.

Basic Information

Product Name	5-Fluoro-3-Formyl-1H-Indole-2-Carboxylic Acid Methyl Ester
CAS No.	843629-51-6
Molecular Formula	C11H8FNO3
Molecular Weight	221.18 g/mol
Synonyms	Methyl 5-Fluoro-3-formyl-1H-indole-2-carboxylate; 5-Fluoro-3-formylindole-2-carboxylic acid methyl ester; 1H-Indole-2-carboxylic acid, 5-fluoro-3-formyl-, methyl ester; 843629-51-6; 5-Fluoro-3-formyl-1H-indole-2-carboxylic acid methyl ester; Methyl 5-fluoro-3-formyl-1H-indole-2-carboxylate
EINECS	Contact for details

Quality Control

Our 5-Fluoro-3-Formyl-1H-Indole-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect product stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.