Description

3-Acetylamino-5-Fluoro-1H-Indole-2-Carboxylic Acid Methyl Ester is a high-purity, fluorinated indole derivative that serves as a critical advanced intermediate in modern organic synthesis. Its molecular architecture, featuring both an acetyl-protected amino group and a fluorine substituent, makes it a valuable building block for constructing complex heterocyclic compounds with targeted biological activity. This compound is primarily utilized by research institutions and pharmaceutical development teams engaged in the discovery and synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used as a precursor in the development of new-generation herbicides and fungicides that leverage the fluorine atom for enhanced efficacy.
• Chemical Biology Research: Employed as a probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Fluorinated Compound Library: Serves as a core structure for generating diverse chemical libraries for high-throughput screening in drug discovery.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) laboratories for methodological development in heterocyclic chemistry.

Basic Information

Product Name	3-Acetylamino-5-Fluoro-1H-Indole-2-Carboxylic Acid Methyl Ester
CAS No.	840456-13-5
Molecular Formula	C₁₂H₁₁FN₂O₃
Molecular Weight	250.23 g/mol
Synonyms	Methyl 3-acetamido-5-fluoro-1H-indole-2-carboxylate; 5-Fluoro-3-acetylamino-1H-indole-2-carboxylic acid methyl ester; 3-Acetamido-5-fluoroindole-2-carboxylic acid methyl ester; 840456-13-5; 3-[(Acetylamino)-5-fluoro-1H-indole-2-carboxylic acid methyl ester; Methyl 5-fluoro-3-(acetylamino)-1H-indole-2-carboxylate
EINECS	Contact for details

Quality Control

Our production of 3-Acetylamino-5-Fluoro-1H-Indole-2-Carboxylic Acid Methyl Ester adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.