Description

6-Nitro-1-(4-Trifluoromethyl-Phenyl)-1H-Indazole is a high-purity, advanced pharmaceutical intermediate characterized by its unique indazole core functionalized with nitro and trifluoromethylphenyl groups. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. Pharmaceutical R&D teams and fine chemical manufacturers need this material for developing next-generation drug candidates, leveraging its structural complexity to create molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic research.
• Biochemical Research: Used as a standard or reference compound in enzymatic and receptor binding assays to study structure-activity relationships (SAR).
• Agrochemical Development: Acts as a synthetic intermediate for creating new crop protection agents and pesticides, exploiting the bioactivity of the indazole moiety.
• Material Science Research: Investigated as a monomer or functional additive for creating specialty polymers with unique optical or electronic properties.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations engaged in custom synthesis and process development for client-specific projects.

Basic Information

Product Name	6-Nitro-1-(4-Trifluoromethyl-Phenyl)-1H-Indazole
CAS No.	838820-86-3
Molecular Formula	C14H8F3N3O2
Molecular Weight	307.23 g/mol
Synonyms	6-Nitro-1-[4-(trifluoromethyl)phenyl]-1H-indazole; 1-(4-Trifluoromethylphenyl)-6-nitro-1H-indazole; 6-Nitro-1-(4-trifluoromethylphenyl)indazole; 838820-86-3; 6-Nitro-1-(α,α,α-trifluoro-p-tolyl)-1H-indazole
EINECS	Contact for details

Quality Control

Our production of 6-Nitro-1-(4-Trifluoromethyl-Phenyl)-1H-Indazole adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.