Description

5-Bromo-2-(Trifluoromethyl)-1H-Indole is a high-value halogenated indole derivative, distinguished by its bromine and trifluoromethyl substituents which impart unique electronic and steric properties. This compound serves as a critical advanced pharmaceutical intermediate and versatile building block in modern synthetic chemistry. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and oncology research programs.
• Agrochemical Synthesis: Used in the development of new active ingredients for crop protection products, leveraging its halogenated indole core.
• Material Science Research: Serves as a precursor for functionalized organic molecules used in organic light-emitting diodes (OLEDs) and other electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create diverse compound libraries.
• Fluorine Chemistry: The trifluoromethyl group is valuable for modulating lipophilicity, metabolic stability, and bioavailability in lead optimization.

Basic Information

Product Name	5-Bromo-2-(Trifluoromethyl)-1H-Indole
CAS No.	837392-60-6
Molecular Formula	C9H5BrF3N
Molecular Weight	264.04 g/mol
Synonyms	5-Bromo-2-(trifluoromethyl)-1H-indole; 2-(Trifluoromethyl)-5-bromo-1H-indole; 5-Bromo-2-trifluoromethylindole; 1H-Indole, 5-bromo-2-(trifluoromethyl)-; 837392-60-6
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-2-(Trifluoromethyl)-1H-Indole adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by advanced analytical techniques including HPLC, GC-MS, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.