Description

Acumapimod (BCT-197) is a potent and selective inhibitor of p38 mitogen-activated protein kinase (MAPK) alpha, a key signaling protein involved in inflammatory pathways. This compound matters for its significant role in preclinical research focused on modulating cytokine production and cellular stress responses. Pharmaceutical R&D teams and academic researchers in the fields of immunology, oncology, and inflammatory diseases require high-purity Acumapimod to investigate novel therapeutic mechanisms and validate drug targets.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel anti-inflammatory and anti-cancer therapeutics.
• Biochemical Assay Development: Used as a selective tool compound in high-throughput screening (HTS) and in vitro assays to study p38 MAPK signaling pathways and inhibitor efficacy.
• Mechanism of Action Studies: Employed in cellular and animal models to elucidate the role of p38α in disease pathology, including rheumatoid arthritis, chronic obstructive pulmonary disease (COPD), and certain cancers.
• Academic & Contract Research: Essential for universities and CROs conducting fundamental research on kinase biology, inflammation, and cell stress responses.
• Preclinical Candidate Optimization: Used in structure-activity relationship (SAR) studies to design and optimize next-generation p38 inhibitors with improved potency and selectivity profiles.

Basic Information

Product Name	Acumapimod (BCT-197)
CAS No.	836683-15-9
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	BCT-197; BCT197; 5-(2,6-Dichloro-4-pyridinyl)-3-[(1S)-1-(4-pyridinyl)ethyl]-1,3,4-oxadiazol-2(3H)-one; (S)-5-(2,6-Dichloropyridin-4-yl)-3-(1-(pyridin-4-yl)ethyl)-1,3,4-oxadiazol-2(3H)-one; p38 MAPK inhibitor BCT-197; Losmapimod analog; GW856553 analog
EINECS	Contact for details

Quality Control

Our Acumapimod (BCT-197) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98% by HPLC), and impurity profiles. We adhere to relevant industry standards for research chemicals, and specifications can be aligned with client requirements for advanced R&D use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere or with desiccant for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.