Description

Methyl 3-Amino-5-Fluoro-Benzo[B]Thiophene-2-Carboxylate is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines a benzo[b]thiophene scaffold with strategically placed amino and fluoro substituents, enabling precise molecular modifications. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Agrochemical Research: Serves as a critical building block for developing new-generation herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Used in the research and development of advanced organic electronic materials, such as organic semiconductors and light-emitting diodes (OLEDs).
• Dye & Pigment Synthesis: Acts as a specialized intermediate for creating high-performance, color-fast dyes and functional pigments.
• Chemical Biology Probe Development: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis projects requiring complex, fluorinated heterocyclic structures.

Basic Information

Product Name	Methyl 3-Amino-5-Fluoro-Benzo[B]Thiophene-2-Carboxylate
CAS No.	835912-83-9
Molecular Formula	C10H8FNO2S
Molecular Weight	225.24 g/mol
Synonyms	Methyl 3-Amino-5-Fluorobenzo[b]thiophene-2-carboxylate; 3-Amino-5-Fluorobenzo[b]thiophene-2-carboxylic Acid Methyl Ester; 5-Fluoro-3-aminobenzo[b]thiophene-2-carboxylic acid methyl ester; 2-Carbomethoxy-3-amino-5-fluorobenzo[b]thiophene; Methyl 5-Fluoro-3-aminobenzo[b]thiophene-2-carboxylate; 835912-83-9; 3-Amino-5-fluoro-1-benzothiophene-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3-Amino-5-Fluoro-Benzo[B]Thiophene-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.