Description

2-Amino-4-(4-Difluoromethoxy-Phenyl)-Thiophene-3-Carboxylic Acid Methyl Ester is a high-value, multifunctional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to innovate and scale new therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting various disease pathways.
• Agrochemical Synthesis: Serves as a versatile building block in the creation of novel herbicides, fungicides, and insecticides, leveraging the thiophene and difluoromethoxy pharmacophores.
• Material Science Research: Used in the synthesis of advanced organic materials, including organic semiconductors and liquid crystals, due to its electron-rich thiophene core.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional laboratories for methodological development in heterocyclic and fluorine chemistry.

Basic Information

Product Name	2-Amino-4-(4-Difluoromethoxy-Phenyl)-Thiophene-3-Carboxylic Acid Methyl Ester
CAS No.	832737-30-1
Molecular Formula	C13H11F2NO3S
Molecular Weight	299.29 g/mol
Synonyms	Methyl 2-amino-4-[4-(difluoromethoxy)phenyl]thiophene-3-carboxylate; 2-Amino-4-(4-difluoromethoxyphenyl)thiophene-3-carboxylic acid methyl ester; 832737-30-1; Thiophene-3-carboxylic acid, 2-amino-4-[4-(difluoromethoxy)phenyl]-, methyl ester; Methyl 2-amino-4-(4-difluoromethoxyphenyl)thiophene-3-carboxylate
EINECS	Contact for details

Quality Control

Our 2-Amino-4-(4-Difluoromethoxy-Phenyl)-Thiophene-3-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.