Description

Thiazole, 4-Methyl-2-[(2R,3S,4R)-4-Methyl-1-Oxaspiro[2.5]Oct-2-Yl]-, Rel- is a high-purity, stereochemically defined organic compound featuring a complex spirocyclic oxirane fused to a substituted thiazole ring. This specific molecular architecture makes it a critical chiral intermediate for advanced pharmaceutical synthesis and fine chemical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients with precise three-dimensional structures.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides where specific stereochemistry is crucial for bioactivity.
• Asymmetric Synthesis: Serves as a sophisticated starting material or reagent in catalytic asymmetric reactions to introduce complex stereocenters.
• Fine Chemical Production: Intermediate for manufacturing high-value specialty chemicals, including flavors, fragrances, and advanced materials.
• Academic & Contract Research: Essential for methodological studies in organic chemistry and for contract research organizations (CROs) serving the life sciences sector.

Basic Information

Product Name	Thiazole, 4-Methyl-2-[(2R,3S,4R)-4-Methyl-1-Oxaspiro[2.5]Oct-2-Yl]-, Rel-
CAS No.	831224-87-4
Molecular Formula	C12H17NO2S
Molecular Weight	239.33 g/mol
Synonyms	rel-(2R,3S,4R)-4-Methyl-2-(4-methylthiazol-2-yl)-1-oxaspiro[2.5]octane; 4-Methyl-2-[(2R,3S,4R)-4-methyl-1-oxaspiro[2.5]oct-2-yl]thiazole; (rel)-(2R,3S,4R)-2-(4-Methyl-1,3-thiazol-2-yl)-4-methyl-1-oxaspiro[2.5]octane; Spirooxirane-thiazole derivative; Chiral thiazole-spirooxirane intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) with full analytical data are provided for each lot. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be sensitive to moisture and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.