Description

4-(4-Difluoromethoxy-Phenyl)-Pyrimidine-2-Thiol is a high-purity, sulfur-containing heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluoromethoxy and thiol functionalities enable precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate this sophisticated scaffold into new molecular entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyrimidine-thiol core.
• Ligand Synthesis: Serves as a building block for creating complex ligands used in catalysis and material science.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Advanced Material Development: A monomer or precursor for functional polymers and organic electronic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific research and scale-up projects.

Basic Information

Product Name	4-(4-Difluoromethoxy-Phenyl)-Pyrimidine-2-Thiol
CAS No.	828273-06-9
Molecular Formula	C11H7F2N2OS
Molecular Weight	253.25 g/mol
Synonyms	4-(4-Difluoromethoxyphenyl)pyrimidine-2-thiol; 2-Mercapto-4-(4-difluoromethoxyphenyl)pyrimidine; 4-(4-Difluoromethoxyphenyl)-2-pyrimidinethiol; 2-Pyrimidinethiol, 4-[4-(difluoromethoxy)phenyl]-; 828273-06-9; 4-(4-(Difluoromethoxy)phenyl)pyrimidine-2-thiol
EINECS	Contact for details

Quality Control

Our 4-(4-Difluoromethoxy-Phenyl)-Pyrimidine-2-Thiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and potential for oxidation, it is recommended to handle under an inert atmosphere for long-term storage and to minimize repeated exposure to air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.