Description

Rel-(1R,4S,4Ar,8S,8As)-4,4A,8,8A-Tetrahydro-8-Methoxy-8-Methyl-1,4-Methanonaphthalen-5(1H)-One is a high-purity, stereochemically defined bicyclic ketone intermediate of significant interest in advanced organic synthesis. Its rigid, functionalized structure makes it a valuable chiral building block for constructing complex molecular architectures. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the research and development of new therapeutic agents, particularly for central nervous system (CNS) targets.
• Agrochemical Synthesis: Used in the development of novel, stereospecific pesticides and herbicides where the defined spatial orientation is critical for bioactivity.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in academic and industrial research focused on developing new catalytic methodologies.
• Fine Chemical Production: Acts as a specialized intermediate for the manufacture of high-value flavors, fragrances, and performance materials requiring specific stereochemistry.
• Material Science: Investigated as a monomer or cross-linking agent for creating polymers with unique thermal or mechanical properties derived from its strained bicyclic framework.

Basic Information

Product Name	Rel-(1R,4S,4Ar,8S,8As)-4,4A,8,8A-Tetrahydro-8-Methoxy-8-Methyl-1,4-Methanonaphthalen-5(1H)-One
CAS No.	828248-60-8
Molecular Formula	C₁₃H₁₆O₂
Molecular Weight	204.26 g/mol
Synonyms	8-Methoxy-8-methyl-1,4-methano-4a,5,8,8a-tetrahydro-1,4-methanonaphthalen-5(1H)-one; (1R,4S,4aR,8S,8aS)-8-Methoxy-8-methyl-1,4-methano-1,4,4a,5,8,8a-hexahydronaphthalen-5-one; Bicyclo[2.2.1]hept-5-ene-2-methanol, 1-methoxy-7-oxo-, (1R,4S,4aR,8S,8aS)-rel-; 828248-60-8; Methanonaphthalenone derivative
EINECS	Contact for details

Quality Control

Every batch of Rel-(1R,4S,4Ar,8S,8As)-4,4A,8,8A-Tetrahydro-8-Methoxy-8-Methyl-1,4-Methanonaphthalen-5(1H)-One is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and stereochemical integrity, with specifications tailored to research and cGMP-grade requirements. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting critical parameters such as chiral purity and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.