Description

Methyl 2-Amino-4-Methyl-5-(tert-Butoxycarbonyl)-Thiophene-3-Carboxylate is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. This compound matters because it provides a protected, reactive scaffold essential for constructing complex molecules with precision and efficiency. It is primarily needed by R&D and production chemists in the pharmaceutical and agrochemical industries for applications such as drug discovery and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel thiophene-based drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Serves as a crucial building block for developing new generation herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Precursor: Used in the research and development of organic semiconductors, conductive polymers, and advanced electronic materials.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis services and scale-up production of specialty chemicals.
• Academic & Institutional Research: Employed in universities and research institutes for methodological studies in heterocyclic and medicinal chemistry.
• Peptidomimetics Development: The tert-butoxycarbonyl (Boc) protected amine and ester functionalities make it valuable for creating thiophene-based peptidomimetics.

Basic Information

Product Name	Methyl 2-Amino-4-Methyl-5-(tert-Butoxycarbonyl)-Thiophene-3-Carboxylate
CAS No.	827614-43-7
Molecular Formula	C12H17NO4S
Molecular Weight	271.33 g/mol
Synonyms	Methyl 2-amino-4-methyl-5-[(2-methylpropan-2-yl)oxycarbonyl]thiophene-3-carboxylate; 2-Amino-4-methyl-5-(tert-butoxycarbonyl)thiophene-3-carboxylic acid methyl ester; Methyl 2-amino-4-methyl-5-Boc-thiophene-3-carboxylate; 5-Boc-2-amino-4-methylthiophene-3-carboxylic acid methyl ester; 3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; Boc-protected aminomethylthiophene carboxylate; 827614-43-7 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our Methyl 2-Amino-4-Methyl-5-(tert-Butoxycarbonyl)-Thiophene-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.