Description

4-(Trifluoromethyl)Benzo[B]Thiophene-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block characterized by its benzo[b]thiophene core and trifluoromethyl and carboxylic acid functional groups. This compound is essential for advanced organic synthesis, particularly in the development of novel pharmaceuticals and agrochemicals, where its unique structure imparts desirable properties like metabolic stability and enhanced lipophilicity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in kinase inhibitor and anti-inflammatory agent discovery.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides, leveraging the bioactivity of the thiophene and trifluoromethyl motifs.
• Material Science Precursor: Serves as a building block for organic semiconductors, liquid crystals, and other functional organic materials.
• Chemical Research & Development: A versatile reagent for academic and industrial research in medicinal and synthetic organic chemistry.
• Fluorinated Compound Library Synthesis: Integral for constructing diverse compound libraries for high-throughput screening in drug discovery.
• Ligand and Catalyst Development: The carboxylic acid group allows for derivatization into chelating ligands for metal catalysis.

Basic Information

Product Name	4-(Trifluoromethyl)Benzo[B]Thiophene-2-Carboxylic Acid
CAS No.	826995-55-5
Molecular Formula	C10H5F3O2S
Molecular Weight	246.21 g/mol
Synonyms	4-(Trifluoromethyl)-1-benzothiophene-2-carboxylic acid; 4-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid; 2-Carboxy-4-(trifluoromethyl)benzo[b]thiophene; 4-Trifluoromethylbenzo[b]thiophene-2-carboxylic acid; 826995-55-5; 4-(Trifluoromethyl)-1-benzothiophene-2-carboxylate; 4-(Trifluoromethyl)benzothiophene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Benzo[B]Thiophene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP standards for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥97.0% (Standard Grade)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.