Description

Benzo[B]Thiophene-2-Carboxylic Acid, 5-Bromo-3-(Trifluoromethyl)- is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. Its core value lies in the strategic combination of a bromo substituent and a trifluoromethyl group on the benzo[b]thiophene scaffold, enabling precise molecular modifications and the introduction of key physicochemical properties. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a critical intermediate in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiophene core and fluorine atoms.
• Material Science Research: Serves as a precursor for organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs), due to its conjugated system.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Building Block: The trifluoromethyl group makes it a valuable reagent for introducing fluorine atoms to enhance metabolic stability and lipophilicity in target molecules.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for custom synthesis projects requiring complex, halogenated heterocycles.

Basic Information

Product Name	Benzo[B]Thiophene-2-Carboxylic Acid, 5-Bromo-3-(Trifluoromethyl)-
CAS No.	826995-52-2
Molecular Formula	C10H4BrF3O2S
Molecular Weight	325.10 g/mol
Synonyms	5-Bromo-3-(trifluoromethyl)benzo[b]thiophene-2-carboxylic acid; 5-Bromo-3-(trifluoromethyl)-1-benzothiophene-2-carboxylic acid; 2-Benzothiophenecarboxylic acid, 5-bromo-3-(trifluoromethyl)-; 826995-52-2; 5-Bromo-3-trifluoromethylbenzo[b]thiophene-2-carboxylic acid; BTBTA
EINECS	Contact for details

Quality Control

Our Benzo[B]Thiophene-2-Carboxylic Acid, 5-Bromo-3-(Trifluoromethyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent batch-to-batch reliability essential for sensitive R&D and scale-up processes. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be light-sensitive and should be handled under inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.