Description

1H-Imidazole,4,5-Dihydro-2-[(1R)-1,2,3,4-Tetrahydro-1-Methyl-1-Naphthalenyl]-(9Ci) CAS NO 824977-92-6 is a chiral, tetrahydronaphthalene-substituted imidazoline derivative, a sophisticated organic intermediate prized for its unique stereochemistry and structural complexity. This compound is critical for research and development in advanced pharmaceutical synthesis, particularly in the creation of novel active pharmaceutical ingredients (APIs) with specific stereochemical requirements. It is primarily sought by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its rigid, fused-ring scaffold.
• Asymmetric Synthesis: Serves as a chiral auxiliary or precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Agrochemical Development: Potential intermediate in the research and synthesis of advanced pesticides and herbicides with specific activity profiles.
• Ligand Synthesis: Can be utilized for the development of novel chiral ligands for metal-catalyzed reactions.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	1H-Imidazole,4,5-Dihydro-2-[(1R)-1,2,3,4-Tetrahydro-1-Methyl-1-Naphthalenyl]-(9Ci)
CAS No.	824977-92-6
Molecular Formula	C₁₄H₁₈N₂
Molecular Weight	214.31 g/mol
Synonyms	(R)-2-(1-Methyl-1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole; (1R)-2-(1-Methyl-1,2,3,4-tetrahydronaphthalen-1-yl)-2-imidazoline; 2-[(1R)-1-Methyl-1,2,3,4-tetrahydronaphthalen-1-yl]-4,5-dihydro-1H-imidazole; (R)-1-Methyl-1-(4,5-dihydro-1H-imidazol-2-yl)-1,2,3,4-tetrahydronaphthalene; Tetralin-substituted imidazoline; Chiral imidazoline derivative; 824977-92-6; SCHEMBL21806227
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, GC, and NMR to confirm identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support development and commercial projects with GMP-compatible processes and documentation upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed under an inert atmosphere if long-term storage is required to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.