Description

(1R)-8,9-Dichloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine is a high-purity chiral benzazepine derivative, identified by CAS number 824430-76-4. This compound is a critical pharmaceutical intermediate valued for its defined stereochemistry and structural complexity, enabling the synthesis of targeted active pharmaceutical ingredients (APIs). It is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of central nervous system (CNS) targeted drugs and receptor modulators.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and novel drug candidate discovery.
• Process Chemistry: Serves as a starting material or advanced intermediate in the optimization and scale-up of API manufacturing processes.
• Reference Standard: Employed as an analytical standard for quality control and method development in regulatory submissions.
• Chemical Biology: Utilized as a probe or ligand in biochemical assays to study specific biological pathways and receptor interactions.

Basic Information

Item	Details
Product Name	(1R)-8,9-Dichloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine
CAS No.	824430-76-4
Molecular Formula	C11H13Cl2N
Molecular Weight	230.13 g/mol
Synonyms	(R)-8,9-Dichloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; (1R)-8,9-Dichloro-1-methyl-1,2,3,4,5-tetrahydro-3-benzazepine; 1H-3-Benzazepine, 8,9-dichloro-2,3,4,5-tetrahydro-1-methyl-, (1R)-; 824430-76-4; (R)-8,9-Dichloro-1-methyl-1,2,3,4,5-tetrahydro-3H-3-benzazepine; (1R)-1-Methyl-8,9-dichloro-2,3,4,5-tetrahydro-1H-3-benzazepine
EINECS	Contact for details

Quality Control

Our (1R)-8,9-Dichloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity research and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a dry environment and opened under inert atmosphere when handling is required for extended periods.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.