Description

Thiazole, 2-[(4,4-Difluoro-3-Butenyl)Thio]-4,5-Dihydro-4-Methyl-, (4S)- (9Ci) is a high-value, stereochemically defined sulfur- and fluorine-containing heterocyclic compound. This advanced intermediate is critical for its role in the synthesis of complex bioactive molecules, offering unique reactivity and structural motifs. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS, anti-infective, or metabolic diseases.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the thiazole core and fluorine atoms can enhance biological activity and environmental stability.
• Chemical Biology Probe Synthesis: Serves as a precursor for creating specialized molecular probes and tool compounds used in biochemical and pharmacological research.
• Material Science Research: Potential intermediate for the development of specialty chemicals, ligands for catalysis, or advanced materials with specific electronic properties.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale production of target molecules in both industrial and academic settings.

Basic Information

Product Name	Thiazole, 2-[(4,4-Difluoro-3-Butenyl)Thio]-4,5-Dihydro-4-Methyl-, (4S)- (9Ci)
CAS No.	824391-27-7
Molecular Formula	C9H13F2NS2
Molecular Weight	237.33 g/mol
Synonyms	(4S)-2-[(4,4-Difluorobut-3-en-1-yl)thio]-4-methyl-4,5-dihydrothiazole; (S)-2-((4,4-Difluorobut-3-en-1-yl)thio)-4-methyl-4,5-dihydrothiazole; 2-[(4,4-Difluoro-3-butenyl)thio]-4,5-dihydro-4-methyl-, (4S)-Thiazole; 4,5-Dihydro-4-methyl-2-[[(4,4-difluoro-3-butenyl)thio]thiazole, (S)-; 824391-27-7; (S)-4-Methyl-2-((4,4-difluorobut-3-en-1-yl)thio)-4,5-dihydrothiazole
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity (typically by HPLC), chiral purity, and impurity profiles to ensure it meets the exacting standards required for research and development. Our quality systems support compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to fluoride/strong alkali conditions and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.