Description

6'-Amino-Spiro[Cyclopropane-1,3'-[3H]Indol]-2'(1'H)-One CAS NO 811803-24-4 is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic indole scaffold. This compound is valued for its role as a critical building block in the synthesis of novel bioactive molecules, particularly in medicinal chemistry research and development. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, especially within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in constructing bifunctional molecules designed for targeted protein degradation.
• Chemical Biology Probes: Employed in the development of tool compounds for investigating biological mechanisms and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global pharmaceutical innovation.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic and pharmacological studies.

Basic Information

Product Name	6'-Amino-Spiro[Cyclopropane-1,3'-[3H]Indol]-2'(1'H)-One
CAS No.	811803-24-4
Molecular Formula	C10H9N3O
Molecular Weight	187.20 g/mol
Synonyms	6'-Amino-1'H-spiro[cyclopropane-1,3'-indol]-2'-one; 6'-Amino-spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one; 2H-Spiro[cyclopropane-1,3'-indole]-2'-one, 6'-amino-1',2'-dihydro-; 6'-Amino-1'H-spiro[cyclopropane-1,3'-indol]-2'(3'H)-one; 6-Amino-spiro(cyclopropane-1,3'-indolin)-2'-one; 811803-24-4; Spiro[cyclopropane-1,3'-indol]-2'(1'H)-one, 6'-amino-
EINECS	Contact for details

Quality Control

Our 6'-Amino-Spiro[Cyclopropane-1,3'-[3H]Indol]-2'(1'H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and rigorous control of residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.