Description

Spiro[Isoquinoline-1(2H),4-Piperidin]-3(4H)-One, 1-Methyl- (8Ci) CAS NO 801164-52-3 is a high-purity, advanced pharmaceutical intermediate belonging to the spirocyclic heterocycle class. This compound is valued for its complex molecular architecture, which serves as a critical building block in modern medicinal chemistry. It is primarily sought by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used as a core scaffold or building block for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• API Synthesis: Employed in the multi-step synthesis of complex target molecules for preclinical and clinical development.
• Biochemical Tool Compound: May be utilized in biochemical assays to study specific enzyme interactions or receptor binding mechanisms.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for pharmaceutical clients.

Basic Information

Product Name	Spiro[Isoquinoline-1(2H),4-Piperidin]-3(4H)-One, 1-Methyl- (8Ci)
CAS No.	801164-52-3
Molecular Formula	C14H16N2O
Molecular Weight	228.29 g/mol
Synonyms	1-Methylspiro[isoquinoline-1(2H),4'-piperidin]-3(4H)-one; 1-Methyl-1-azaspiro[4.5]decane-2,8-dione derivative (related); Spiro[Isoquinoline-1(2H),4'-piperidine]-3(4H)-one, 1-methyl-; 801164-52-3; 1-Methylspiro[2H-isoquinoline-1,4'-piperidine]-3(4H)-one; 1-Methyl-3-oxo-1,2,3,4-tetrahydrospiro[isoquinoline-4,4'-piperidine]; Spirocyclic isoquinolinone derivative
EINECS	Contact for details

Quality Control

Our Spiro[Isoquinoline-1(2H),4-Piperidin]-3(4H)-One, 1-Methyl- (8Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP guidelines for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.