Description

5-Cyano-6-Azaindole-2-Carboxylic Acid Ethyl Ester is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in its unique fused azaindole scaffold, which serves as a privileged structure for modulating biological activity and physicochemical properties in drug discovery. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients targeting a range of therapeutic areas and crop protection solutions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, particularly for oncology and inflammatory disease targets.
• Agrochemical Research: Used as a core scaffold for developing new herbicides, fungicides, and insecticides with novel modes of action.
• Chemical Biology Probe Development: Serves as a versatile starting point for creating tool compounds to study specific enzyme functions and biological pathways.
• Material Science: Potential building block for advanced organic electronic materials due to its electron-deficient aromatic system.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke molecules for client R&D programs.
• Academic Research: Utilized in university and institutional labs for methodological development in heterocyclic and medicinal chemistry.

Basic Information

Product Name	5-Cyano-6-Azaindole-2-Carboxylic Acid Ethyl Ester
CAS No.	800401-87-0
Molecular Formula	C11H9N3O2
Molecular Weight	215.21 g/mol
Synonyms	Ethyl 5-Cyano-1H-pyrrolo[2,3-b]pyridine-2-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 5-cyano-, ethyl ester; 6-Azaindole-2-carboxylic acid, 5-cyano-, ethyl ester; 5-Cyano-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester; AZD-1480 Intermediate; Pyrrolopyridine derivative
EINECS	Contact for details

Quality Control

Our 5-Cyano-6-Azaindole-2-Carboxylic Acid Ethyl Ester is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our standard grade meets typical research and development specifications, with custom purity levels available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.