Description

Pyrrolo[2,1-A]Isoquinolin-3(2H)-One, 1,5,6,10B-Tetrahydro-2-Hydroxy-2-Methyl-, (2R,10Bs)-Rel- (9Ci) is a high-purity, stereochemically defined heterocyclic compound of significant interest in advanced organic synthesis. This molecule serves as a critical chiral building block and intermediate for pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology therapeutic areas.
• Asymmetric Synthesis: Utilized as a sophisticated building block in stereoselective synthesis to introduce complex fused-ring systems with defined stereochemistry.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Agrochemical Development: Potential intermediate in the synthesis of advanced crop protection agents requiring specific stereoisomers.
• Academic & Contract Research: Used in university and CRO laboratories for methodological development and the study of novel heterocyclic reactions.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, dyes, and advanced materials requiring the pyrroloisoquinoline scaffold.

Basic Information

Product Name	Pyrrolo[2,1-A]Isoquinolin-3(2H)-One, 1,5,6,10B-Tetrahydro-2-Hydroxy-2-Methyl-, (2R,10Bs)-Rel- (9Ci)
CAS No.	800374-51-0
Molecular Formula	C₁₃H₁₅NO₂
Molecular Weight	217.26 g/mol
Synonyms	(2R,10bS)-rel-1,5,6,10b-Tetrahydro-2-hydroxy-2-methylpyrrolo[2,1-a]isoquinolin-3(2H)-one; rel-(2R,10bS)-1,5,6,10b-Tetrahydro-2-hydroxy-2-methylpyrrolo[2,1-a]isoquinolin-3(2H)-one; Pyrrolo[2,1-a]isoquinolin-3(2H)-one, 1,5,6,10b-tetrahydro-2-hydroxy-2-methyl-, (2R,10bS)-rel-; 800374-51-0; UNII-8J7D4Z7U3S; 8J7D4Z7U3S
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles, typically determined by HPLC, GC, and chiral analysis methods. Our quality assurance system is designed to meet the stringent requirements of pharmaceutical R&D and cGMP guidelines for investigational materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.