Description

D-Leucine-2-D is a deuterium-labeled isotopologue of the essential amino acid D-leucine, specifically designed for advanced research and analytical applications. This compound matters for its critical role in metabolic pathway tracing, protein structure elucidation, and as a stable internal standard in mass spectrometry, ensuring unparalleled accuracy in quantitative analysis. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and analytical laboratories focused on drug discovery, proteomics, and stable isotope labeling studies.

Application

• As a stable isotope-labeled internal standard for the precise quantification of leucine and related metabolites via LC-MS/MS and GC-MS.
• In metabolic flux analysis and tracer studies to investigate protein synthesis, degradation, and amino acid metabolism pathways.
• For structural research in nuclear magnetic resonance (NMR) spectroscopy, utilizing deuterium as a probe.
• In the development and validation- As a key building block in the synthesis of deuterated peptides and other complex biomolecules for research purposes.
  • For use in nutritional research to study amino acid uptake, utilization, and turnover in biological systems.

Basic Information

Product Name	D-Leucine-2-D
CAS No.	89836-92-0
Molecular Formula	C6H12DNO2
Molecular Weight	132.18 g/mol
Synonyms	(2S)-2-Amino-4-methyl-2-deuteriopentanoic acid; (S)-2-Amino-4-methyl-2-deuteriopentanoic acid; D-Leucine-2-d; D-Leucine-2-d1; (S)-Leucine-2-d; Leucine-2-d (D-form); (S)-2-Deuterioleucine; Deuterated D-Leucine
EINECS	Contact for details

Quality Control

Our D-Leucine-2-D is manufactured under strict quality systems to ensure high isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (D%), chemical purity, and chiral purity. We adhere to cGMP principles for research chemicals, and specifications can be tailored to meet the rigorous standards of pharmaceutical R&D and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Isotopic Purity (D%)	≥98.0 atom % D
Chiral Purity (HPLC)	≥99.0% D-isomer
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.