Description

n-Acetyl-Dl-Aspartic-2,3,3-D3 Acid is a deuterated derivative of N-acetyl aspartic acid, a key compound in neurochemistry and metabolic research. This isotopically labeled version is essential for creating internal standards in mass spectrometry, enabling highly accurate quantification and metabolic pathway tracing. It is primarily used by pharmaceutical researchers, analytical laboratories, and manufacturers of diagnostic reagents for advanced studies in neurology and metabolomics.

Application

• Mass Spectrometry Internal Standard: Serves as a critical reference compound for the precise quantification of N-acetyl aspartic acid in biological samples via LC-MS and GC-MS.
• Metabolic Pathway Research: Used as a stable isotope-labeled tracer to study the role of N-acetyl aspartate in brain metabolism and neurological function.
• Pharmaceutical Development: Employed in the research and quality control of drug candidates targeting neurological disorders, such as Canavan disease and mitochondrial defects.
• Diagnostic Reagent Manufacturing: A key component in the production of calibration kits and assays for clinical diagnostics related to inborn errors of metabolism.
• Biochemical Research: Utilized in enzymatic studies and as a substrate or inhibitor in investigations of aspartoacylase activity.
• NMR Spectroscopy: Acts as a deuterated standard for nuclear magnetic resonance studies due to its specific isotopic labeling.

Basic Information

Product Name	n-Acetyl-Dl-Aspartic-2,3,3-D3 Acid
CAS No.	89829-69-6
Molecular Formula	C6H6D3NO5
Molecular Weight	177.15 g/mol
Synonyms	N-Acetyl-DL-aspartic-2,3,3-d3 Acid; 2-(Acetylamino)-3,3-dideuterio-2-deuteriobutanedioic Acid; N-Acetyl-DL-aspartic Acid-d3; Deuterated N-Acetyl Aspartic Acid; NAA-d3; N-Acetylaspartic Acid-d3; (2R/S)-2-Acetamido-3,3-dideuterio-2-deuteriosuccinic Acid; Ac-Asp-OH-d3
EINECS	Contact for details

Quality Control

Every batch of n-Acetyl-Dl-Aspartic-2,3,3-D3 Acid is produced and tested under a strict quality management system. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR and mass spectrometry to confirm deuteration level and identity. A Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure and deuteration pattern
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.