Description

Tiamulin Fumarate is a semi-synthetic pleuromutilin derivative antibiotic, specifically formulated as the fumarate salt to enhance stability and bioavailability. This compound is critically important for its potent activity against Gram-positive bacteria and mycoplasmas, making it a cornerstone in veterinary medicine. It is primarily needed by manufacturers in the animal health and pharmaceutical industries for the formulation of premixes, water-soluble powders, and injectables to control respiratory and enteric diseases in swine and poultry.

Application

• Veterinary Pharmaceutical Formulations: Primary active ingredient in injectable solutions and oral powders for the treatment of swine dysentery and enzootic pneumonia.
• Animal Feed Additives: Incorporated into medicated premixes and complete feeds for prophylactic and therapeutic use in livestock.
• Poultry Health Management: Used to control and treat chronic respiratory disease (CRD) caused by *Mycoplasma gallisepticum* in chickens and turkeys.
• Aquaculture Applications: Investigated for use in controlling bacterial infections in farmed fish, subject to regional regulatory approvals.
• Reference Standard: Serves as a high-purity analytical standard for quality control testing in regulatory and laboratory settings.
• Research & Development: Used in microbiological and pharmacological research to study antibiotic resistance mechanisms and develop new derivative compounds.

Basic Information

Product Name	Tiamulin Fumarate
CAS No.	89708-74-7
Molecular Formula	C28H47NO8S · C4H4O4
Molecular Weight	609.73 g/mol
Synonyms	Tiamutin; Tiamulin hydrogen fumarate; 14-Deoxy-14-[(2-diethylaminoethyl)mercaptoacetoxy]mutilin hydrogen fumarate; Dynamutilin; (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-Ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propano-3aH-cyclopentacycloocten-8-yl 2-[(diethylamino)ethylthio]acetate hydrogen fumarate; Denagard (Veterinary Preparations); Vetmulin
EINECS	Contact for details

Quality Control

Our Tiamulin Fumarate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and related substances, to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) are provided with each shipment, detailing all critical parameters. We can supply material compliant with various pharmacopeial monographs upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC, anhydrous basis)	97.0% - 102.0%
Water (Karl Fischer)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.