Description

Androsterone-2,2,4,4-D4 is a high-purity, deuterium-labeled analog of the endogenous steroid hormone androsterone, specifically designed for use as an internal standard in advanced analytical techniques. This stable isotope-labeled compound is critical for ensuring the accuracy and reliability of quantitative measurements in complex biological matrices. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, clinical diagnostics, and forensic toxicology sectors who require precise and reproducible results in steroid hormone analysis.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the analysis of endogenous androsterone and related steroid metabolites.
• Clinical Research & Diagnostics: Used in the development and validation of assays for diagnosing endocrine disorders, monitoring hormone replacement therapy, and conducting metabolic studies.
• Pharmaceutical Development: Supports pharmacokinetic (PK) and pharmacodynamic (PD) studies, bioequivalence testing, and the quantification of steroid-based drug compounds and their metabolites.
• Forensic & Doping Control: Essential for the accurate detection and quantification of anabolic steroids and their metabolites in anti-doping programs and forensic investigations.
• Metabolomics & Biomarker Discovery: Enables precise profiling of steroid pathways in metabolomic studies aimed at discovering new disease biomarkers.
• Reference Material: Serves as a certified reference material (CRM) for calibrating instruments and validating analytical methods in accredited laboratories.

Basic Information

Item	Details
Product Name	Androsterone-2,2,4,4-D4
CAS No.	89685-10-9
Molecular Formula	C19H26D4O2
Molecular Weight	294.46 g/mol (approx.)
Synonyms	3α-Hydroxy-5α-androstan-17-one-2,2,4,4-D4; 5α-Androstan-3α-ol-17-one-2,2,4,4-D4; Deuterated Androsterone; Androsterone-d4; [2,2,4,4-2H4]-Androsterone; Isoandrosterone-d4 (related); Etiocholan-3α-ol-17-one-d4; 17-Oxo-5α-androstan-3α-ol-d4
EINECS	Contact for details

Quality Control

Every batch of Androsterone-2,2,4,4-D4 is manufactured and analyzed under strict quality management systems to ensure the highest standards of isotopic purity and chemical identity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with the stringent requirements for analytical reference standards. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (Titration)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.