Description

Bicyclo[2.1.1]Hexan-1-Amine, Hydrochloride (1:1) is a specialized bicyclic amine salt of significant interest in advanced organic synthesis and pharmaceutical research. Its unique, highly strained bicyclo[2.1.1]hexane scaffold makes it a valuable building block for developing novel molecular architectures with tailored physical and biological properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications in medicinal chemistry, ligand design, and the synthesis of complex, three-dimensional frameworks.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce conformational constraint and improve metabolic stability of drug candidates.
• Agrochemical Synthesis: Employed in the development of novel herbicides, fungicides, and insecticides that require rigid, three-dimensional amine components.
• Ligand and Catalyst Development: Acts as a precursor for chiral amines and ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Advanced Materials: Incorporated into polymers and specialty chemicals to modify thermal stability, rigidity, and other material properties.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis, exploring new cycloaddition and functionalization reactions.

Basic Information

Product Name	Bicyclo[2.1.1]Hexan-1-Amine, Hydrochloride (1:1)
CAS No.	89676-79-9
Molecular Formula	C6H11N · HCl
Molecular Weight	133.62 g/mol
Synonyms	1-Aminobicyclo[2.1.1]hexane hydrochloride; Bicyclo[2.1.1]hexan-1-amine HCl; (1:1) Bicyclo[2.1.1]hexan-1-amine hydrochloride; 1-Bicyclo[2.1.1]hexylamine hydrochloride; NSC 339063; Aminobicyclo[2.1.1]hexane hydrochloride; Bicyclo[2.1.1]hexane-1-amine hydrochloride
EINECS	Contact for details

Quality Control

Our Bicyclo[2.1.1]Hexan-1-Amine, Hydrochloride (1:1) is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and scale-up. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical development partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.