Description

(R)-1-(4-Methoxy-Benzyl)-2-Methyl-1,2,3,4,5,6,7,8-Octahydro-Isoquinoline is a chiral, non-racemic organic compound belonging to the tetrahydroisoquinoline class, valued for its role as a sophisticated synthetic intermediate. This compound matters because its defined stereochemistry and complex polycyclic structure make it a crucial building block for constructing more complex molecules with specific biological activities. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, process development, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key chiral scaffold in the research and synthesis of potential drug candidates, particularly for central nervous system (CNS) targets, alkaloid analogs, and receptor modulators.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the biological profile of new chemical entities.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective synthesis routes to access enantiomerically pure compounds.
• Agrochemical Development: Acts as a precursor in the creation of novel pesticides or herbicides where the tetrahydroisoquinoline core is pharmacologically relevant.
• Academic & Institutional Research: Utilized in universities and research institutes for methodological development in organic synthesis and catalysis.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, quality control, and regulatory submissions.

Basic Information

Product Name	(R)-1-(4-Methoxy-Benzyl)-2-Methyl-1,2,3,4,5,6,7,8-Octahydro-Isoquinoline
CAS No.	89614-56-2
Molecular Formula	C18H25NO
Molecular Weight	271.40 g/mol
Synonyms	(R)-1-[(4-Methoxyphenyl)methyl]-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline; (R)-1-(4-Methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline; (R)-1-(p-Methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline; (R)-2-Methyl-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline; (R)-1-(4-Methoxy-benzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydro-isoquinoline; (R)-Octahydro-1-(4-methoxybenzyl)-2-methylisoquinoline; (R)-1-(4-Methoxybenzyl)-2-methyl-decahydroisoquinoline (common misnomer).
EINECS	Contact for details

Quality Control

Our (R)-1-(4-Methoxy-Benzyl)-2-Methyl-1,2,3,4,5,6,7,8-Octahydro-Isoquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.