Description

(S)-2-Benzothiazolyl (Z)-2-(5-Amino-1,2,4-Thiadiazol-3-Yl)-2-Methoxyiminothioacetate is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is critical for the synthesis of novel cephalosporin antibiotics, where its specific stereochemistry and functional groups are essential for biological activity. It is primarily required by research institutions and manufacturers in the pharmaceutical industry for the development and production of next-generation antibacterial agents.

Application

• Key Intermediate for Cephalosporin Synthesis: Serves as a crucial building block in the production of advanced third and fourth-generation cephalosporin antibiotics.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for the design and synthesis of new antibacterial compounds with improved efficacy.
• Active Pharmaceutical Ingredient (API) Manufacturing: Incorporated into the final chemical structure of specific antibiotic APIs.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes from laboratory scale to commercial production.
• Biochemical Studies: Utilized in research to study structure-activity relationships (SAR) and mechanisms of bacterial resistance.

Basic Information

Product Name	(S)-2-Benzothiazolyl (Z)-2-(5-Amino-1,2,4-Thiadiazol-3-Yl)-2-Methoxyiminothioacetate
CAS No.	89604-91-1
Molecular Formula	C13H10N6O2S3
Molecular Weight	394.44 g/mol
Synonyms	(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetic acid 2-benzothiazolyl thioester; (Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino-thioacetic acid S-2-benzothiazolyl ester; ATMA Ester; 2-Benzothiazolyl (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminothioacetate; (Z)-ATMA; Cefditoren Pivoxil Intermediate
EINECS	Contact for details

Quality Control

Our production of (S)-2-Benzothiazolyl (Z)-2-(5-Amino-1,2,4-Thiadiazol-3-Yl)-2-Methoxyiminothioacetate adheres to stringent quality systems suitable for pharmaceutical intermediates. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to ensure compliance with your internal specifications and regulatory expectations.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (S-Isomer)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.