Description

2-Acetyl-3-Chlorothiophene is a versatile heterocyclic building block characterized by its acetyl and chloro substituents on the thiophene ring. This compound matters as a critical intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique structure enables the introduction of key functional groups. It is primarily needed by research and development chemists and process engineers in fine chemical manufacturing for creating active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry research.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging its reactive sites for structural diversification.
• Material Science Research: Serves as a precursor for functionalized polymers and organic electronic materials due to the thiophene backbone.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic substitutions, and cyclization processes to construct complex heterocyclic systems.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized colorants and imaging agents.

Basic Information

Product Name	2-Acetyl-3-Chlorothiophene
CAS No.	89581-82-8
Molecular Formula	C6H5ClOS
Molecular Weight	160.62 g/mol
Synonyms	1-(3-Chloro-2-thienyl)ethanone; 3-Chloro-2-acetylthiophene; 3-Chloro-2-thienyl methyl ketone; 2-Acetyl-3-chlorothiophene; 3-Chloro-2-thiophenecarbaldehyde, 1-oxo-; Ethanone, 1-(3-chloro-2-thienyl)-; 3-Chloro-2-thienyl ketone
EINECS	Contact for details

Quality Control

Our 2-Acetyl-3-Chlorothiophene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with cGMP and ISO 9001 standards for reliable integration into your supply chain.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.