Description

(E)-1,1,1-Trifluoro-4-Phenylbut-3-En-2-Ol is a high-purity fluorinated organic building block with a defined stereochemistry, essential for introducing the trifluoromethyl group and a phenyl-substituted enol moiety into complex molecular architectures. This compound matters as a versatile chiral synthon, enabling the synthesis of advanced pharmaceutical intermediates and agrochemicals with enhanced metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral, anti-inflammatory, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group improves lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Asymmetric Catalysis & Ligand Development: Employed as a substrate or a precursor for chiral ligands and catalysts in enantioselective synthesis.
• Fluorine-19 NMR Spectroscopy: Can be used as a reference compound or a probe due to its distinct fluorine signature.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and medicinal chemistry research programs.

Basic Information

Product Name	(E)-1,1,1-Trifluoro-4-Phenylbut-3-En-2-Ol
CAS No.	89524-18-5
Molecular Formula	C10H9F3O
Molecular Weight	202.17 g/mol
Synonyms	(E)-1,1,1-Trifluoro-4-phenyl-3-buten-2-ol; (E)-4-Phenyl-1,1,1-trifluorobut-3-en-2-ol; (E)-α-(Trifluoromethyl)-4-phenyl-3-buten-2-ol; (E)-2-Hydroxy-4-phenyl-1,1,1-trifluoro-2-butene; Trifluoromethyl vinyl carbinol derivative; 89524-18-5; (E)-CF3-Phenylbutenol
EINECS	Contact for details

Quality Control

Our (E)-1,1,1-Trifluoro-4-Phenylbut-3-En-2-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and isomer content are provided with every shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
(E)-Isomer Content (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.