Description

4-Amino-Thiophene-2-Carboxylic Acid Methyl Ester is a versatile heterocyclic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both amino and ester functionalities on a thiophene core, makes it a critical intermediate for constructing complex pharmacologically active molecules. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates targeting various therapeutic areas, including central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiophene scaffold.
• Material Science Research: Serves as a monomer or building block for creating specialized polymers and organic electronic materials with unique conductive or optical properties.
• Chemical Biology & Proteomics: Employed as a scaffold for designing molecular probes, enzyme inhibitors, and activity-based protein profiling (ABPP) reagents.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized heterocyclic dyes and organic pigments due to its electron-rich structure.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	4-Amino-Thiophene-2-Carboxylic Acid Methyl Ester
CAS No.	89499-43-4
Molecular Formula	C6H7NO2S
Molecular Weight	157.19 g/mol
Synonyms	Methyl 4-Aminothiophene-2-carboxylate; 4-Amino-2-thiophenecarboxylic Acid Methyl Ester; 2-Thiophenecarboxylic acid, 4-amino-, methyl ester; Methyl 4-amino-2-thiophenecarboxylate; 4-Amino-2-(methoxycarbonyl)thiophene; 4-Aminothiophene-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 4-Amino-Thiophene-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.