Description

2-Thiophenecarboxylic Acid, 4-Amino-5-Bromo- is a high-purity, multi-functional heterocyclic building block of significant commercial and research interest. Its core value lies in its unique molecular structure, which combines a carboxylic acid group with amino and bromo substituents on a thiophene ring, enabling diverse synthetic modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors who require a reliable, high-quality intermediate for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiophene scaffold.
• Material Science Research: Serves as a monomer or functionalizing agent for creating advanced polymers, conductive materials, and organic semiconductors (OLEDs, OFETs).
• Ligand and Catalyst Development: The amino and carboxylic acid groups make it a versatile starting point for designing novel chelating ligands and organocatalysts.
• Chemical Biology & Proteomics: Employed as a building block for synthesizing molecular probes, enzyme inhibitors, and bioconjugation reagents.
• Custom Synthesis & Contract Manufacturing: A critical raw material for fine chemical companies offering bespoke synthesis services for clients in life sciences.

Basic Information

Item	Details
Product Name	2-Thiophenecarboxylic Acid, 4-Amino-5-Bromo-
CAS No.	89499-42-3
Molecular Formula	C6H4BrNO2S
Molecular Weight	234.07 g/mol
Synonyms	4-Amino-5-bromothiophene-2-carboxylic acid; 5-Bromo-4-aminothiophene-2-carboxylic acid; 4-Amino-5-bromo-2-thiophenecarboxylic acid; 2-Thiophenecarboxylic acid, 4-amino-5-bromo-; 5-Bromo-4-aminothiophene-2-carboxylate; 4-Amino-5-bromo-2-carboxythiophene; 89499-42-3 (CAS Name)
EINECS	Contact for details

Quality Control

Our 2-Thiophenecarboxylic Acid, 4-Amino-5-Bromo- is produced under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and hygroscopic (moisture-sensitive). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.